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- Hormonal activity, such as menstrual cycles and puberty
- Stress, through increased output of hormones from the adrenal (stress) glands.
- Hyperactive sebaceous glands, secondary to the three hormone sources above.
- Diet [citation needed]
- Accumulation of dead skin cells.
- Bacteria in the pores, to which the body becomes 'allergic'.
- Skin irritation or scratching of any sort will activate inflammation.
- Use of anabolic steroids.
- Any medication containing halogens (iodides, chlorides, bromides), lithium, barbiturates, or androgens.
- Exposure to high levels of chlorine compounds, particularly chlorinated dioxins, can cause severe, long-lasting acne, known as Chloracne.
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